IV. Application of the Principle of Precaution by technological means
IV. 1. Relevance of biological parameters studied in terms of public health
J. Youbicier-Simo ; extract from: Electromagnetic Fields and Living Systems, 2002
” The choice of each biological parameter was dictated by its relevance as an indicator of disease states.
It is for this reason that embryo mortality is a marker for the abnormalities that occur during development (teratogenesis).
Abnormal changes in blood levels of ACTH (adrenocorticotropic hormone) and corticosteroids (corticosterone, cortisol) are symptomatic of stress. In addition, corticosteroids are immuno-suppressors, and in healthy individuals, their immuno-suppressive action is counteracted by the immuno-stimulating action of melatonin, which ensures maintenance of the biological parameters relevant to physiologic limits (homeostasis). Subsequently, the prolonged imbalance of this equilibrium outside physiologic limits could have an impact on the body’s defense capabilities in warding off, for example, a microbial attack.
Increased formation of micronuclei in cells can be a sign of cell cycle dysfunction, apoptosis (cell death) or carcinogenesis. Finally, a decrease in neuron proliferation (neurogenesis) in the hippocampus can be associated with short-term memory disorders.
Physiological disorders caused by electromagnetic rays are generally associated with changes in calcium concentrations in target cells. Given that calcium is also an important mediator (second messenger)in most of the important intracellaur biochemical reactions, abnormal changes could be harmful to health. “
(6) See biblio. ref. “6. Transposition of results of experiments in animals to humans
IV . 2 To normalise the biological response to EMFs in animals with CMO
Three animal models were used by Tecnolab: chicken, mice and drosophila . These animals were exposed to electromagnetic radiation from different products: computer screen, television set, mobile telephone, lap-top computer, BTS antenna for mobile telephony.
For each study, the biological effect of normalisation obtained by the compensatory oscillation (CMO) installed on the item emitting the radiation, in comparison with the biological effects of radiation from items that were not equipped and with groups that were not exposed.
Immature organisms (embryo, chick and adult chickens, young healthy mice, i.e. animal models in the growth phase) or compromised subjects (mice with cancer) are used ; since these organisms are known to be the most sensitive to changes in environmental factors.
The use of actual emitting devices for experimental purposes enables the study of the full electromagnetic spectrum of each device, while taking into account actual spectral features of the emitted rays (intensity, frequency, form, phase, magnitude, modulation, etc.), which is not the case when the radiation is simulated in the laboratory with wave generators.
The exposure protocols applied in study animal models are toxicological in kind, i.e. the exposure is either chronic (computer, TV), or repeated (mobile phone, relay station) and long-term (3 to 15 weeks). Experimental approaches of this nature that place animals in extreme exposure conditions offer several advantages. It enables:
- to test actual EMF toxicity thresholds;
to detect sensitive targets;
to predict the impact of long term exposure on a human scale;
to explain probably the absence of biological effects that characterize the great majority of
studies with a too short term exposure
Experimentations and
Results of EM biocompatibility with CMO
(Detailed results, protocols and references of published works available on demand)
2/ a Embryogenesis
The study of embryo mortality rate of a species (chickens) reveals abnormalities that appeared during its development and which led to its death.
This study shows that even for a continuous exposure to the polluting device radiation (leading to the death of the majority of embryos), the compensatory oscillation is capable of maintaining or protecting the fundamental vital processes, reducing the rate of mortality to almost the normal level.
On the contrary, these results highlight the level of severe biological toxicity of EMF from the apparatus that were tested and particularly that of ELFs. Indeed, the virtual elimination, via filtering, of micro-wave radiation from mobile phones did not reduce the level of toxicity (NB. The magnetic field of ELFs may not be filtered or suppressed).
% Mortality of embryos (chickens)
(Youbicier-Simo B-J., Bastide M., 1997-2001University of Montpellier)
| |
CONTROLS |
EXPOSED |
EXPOSED + CMO (Tecno AO) |
| VDU screen |
|
|
|
| (computer and TV) cathodic tubes |
23 % |
57 % |
29 % |
| |
|
|
|
| Portable computer/laptop (LCD) |
|
|
|
| (liquid cristal screens)) |
16 % |
61 % |
31 % |
| |
|
|
|
| Cellular phone |
15 % |
59 % |
27 % |
| Only ELF of a cell phone |
15 % |
76 % |
27 % |
| (microwaves filtered , only. ELFs radiation) |
|
|
|
| |
|
|
|
| GSM BaseTransceiver Station BTS mast (0.9GHz) |
15 % |
|
(in progress) |
| 41V/m - 6V/m - 2V/m |
|
79 - 51 - 32% |
|
2/ b Hormonal system
The production of corticosterone (in young chickens) and cortisol (in mice), both adrenal hormones, is stimulated by the pituitary gland (or hypophysis) in the brain, which is the “crossroads” of hormonal and immune regulations, themselves interdependent. This gland controls biological stress and counteracts inflammatory processes.
The state of biological stress observed in exposed animals returns to normal with the compensatory oscillator. These same results will be shown also in humans, precisely in the study of chronic stress symptoms.
The virtual suppression of the melatonin production under EMF exposure clearly shows the inability of exposed animals to control their stress levels. On the contrary, the presence of the compensatory oscillator enables this hormone to reach normal rates. For that matter, melatonine is well known for being electromagneto-sensitive.
Young chickens - exposed 38 days to VDU screens –computer and TV - (cathode ray tubes)
(Bastide M, 1997 - Youbicier-Simo B-J ,2001 Univ. Montpellier)
Production of corticosterone :
exposed = reduction of 50% compared with controls
exposed + CMO = normal rate equal to controls
* P< 0.05 vs.Exposed
Production of melatonin :
Exposed = reduction of 80% compared with controls
exposed + CMO = normal rate equal to controls
* P< 0.05 vs.Exposed
Mice - exposed for 15 weeks to VDU screens (cathode ray tubes)
(Dr. Faivre-Bonhomme ; University Hospital Paul Brousse, Paris)
Production of cortisol :
Exposed = reduction of 57% compared with controls
exposed + CMO = reduction of 8% compared with controls
* P< 0.05 vs.Exposed or Protected
Health mice - exposed for 5 weeks to cell phone ( GSM )
(Youbicier-Simo B-J , Bastide M., 2001 Univ. Montpellier)
Production of corticosterone :
Exposed = reduction of 30% compared with controls
exposed + CMO = reduction of 12% compared with controls
* P< 0.05 vs. Control
Cancerous mice - exposed for 15 weeks to cell phone ( GSM )
(Youbicier-Simo B-J , Bastide M., 2001 Univ. Montpellier)
Production of corticosterone :
Exposed = reduction of 30% compared with controls
exposed + CMO = normal rate equal to controls
* P< 0.05 vs. Control
Production of ACTH :
Exposed = reduction of 60% compared with controls
exposed + CMO = normal rate equal to controls
+ P < 0.01 vs. Exposed
2/ c Immune system
Simultaneously to hormonal depletions, the production of IgG anti-bodies (immunoglobuline G: a protein of the class of antibodies) is suppressed amongst chickens which are exposed to a cathode ray tube screen, as well as the number of white blood corpuscles (monocytes) decreases, which shows a depression of the immune system. Those that are exposed + CMO show a level of antibodies and a production of monocytes that equals the level shown by those that are not exposed.
Young chickens - exposed 38 days to VDU screens (cathode ray tubes)
(Bastide M, 1997 - Youbicier-Simo B-J ,2001 Univ. Montpellier)
Antibodies production (IgG) :
exposed = reduction of 95% compared with controls
exposed + CMO = normal rate equal to controls
+ P < 0.05 vs. Exposed
Mice - exposed 15 weeks to VDU screens (cathode ray tubes)
(Dr. Faivre-Bonhomme ; Hôpital Paul Brousse, Paris)
Production of monocytes :
exposed = reduction of 58% compared with controls
exposed + CMO = normal rate equal to controls
* P < 0.05 vs. Exposed ; + P < 0.05 vs. Protected
2/ d Neurogenesis
Mice – exposed to cell phones GSM / 11 weeks
Alonso G. - CNRS, Univ. Montpellier ; Youbicier-Simo B-J - Tecnolab
Proliferation of neurones :
exposed = 25% less new neurones compared with controls
exposed + CMO = prolifération equal to controls
* P < 0.01 vs. Control or Protected
2/ e Genome . DNA . Micronuclei
This test consists of counting under microscope the number of fragments of DNA that are present and excessive in the peritoneum macrophages (white corpuscles, cells of the immune system) of animals that have been exposed or those that have been exposed + CMO.
These micronuclei that are present in the cell represent one initial possible step of cancerous process, if these abnormal cells are not eliminated by defence systems of the organism.
Therefore, the high number of cells that include several micronuclei (over 2 cores) for the GSM exposed organisms - clearly shows the impact of its radiation at the fundamental level of the biological system - and the virtual normalisation obtained with the compensatory oscillation (CMO) confirms the results in embryogenesis, as described above.
Mice – exposed to cell phone GSM / 15 weeks
Youbicier-Simo B-J - Tecnolab ; Fernandez A.- CNRS, Univ. Montpellier
Multiplication of DNA micronuclei:
% of cells with more than 2 micro-cores :
exposed = increase of 33% compared with controls
exposed + CMO = 18% compared with controls
* P < 0.01 vs. Control ; + P < 0.01 vs. Exposed
2/ f Calcium
We saw (page 9-10) the key role of calcium in all exchanges between cells, and particularly for the nervous system tissues. The following test measures the concentration of calcium in the cells of the hypophysis, the centre for hormones regulation, and shows that the exposure to GSM radiation doubles its concentration.
At the same time, the release of ACTH (stress hormone) by the same gland is quadrupled. The CMO applied to the GSM brings these both parameters back to normal levels; parameters which are essential factors for the regulation of hormonal and immune systems.
Mice – exposed to cellular phones GSM / 15 weeks
(Dayanithi G – INSERM, Univ Montpellier))
Concentration of intracellular Calcium
in the cells of hypophysis (pituitary gland)
exposed = increase of 100% compared with controls
exposed + CMO = normal compared with controls
* P < 0.001 vs. Control or Exposed and Protected
ACTH hormone release by the cells of the pituitary gland
exposed = increase of 400 % compared with controls
exposed + CMO = normal compared with controls
* P < 0.001 vs. Control or Exposed and Protected
